Water → HCID 136052270, compound

HRID 1889533Notes

Reaction equation

HRID 1889533 reaction equation
[CH2:1]([C:3]1[S:40][C:6]2[N:7]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]4[NH:38][C:37](=[O:39])[O:36][N:35]=4)=[CH:24][CH:23]=3)[C:8](=[O:20])[N:9]([CH2:12][C:13](=[O:19])[C:14]([CH3:18])([CH3:17])[CH2:15][OH:16])[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2].[C:41](OC(=O)C)(=[O:43])[CH3:42].C(OCC)(=O)C.O>N1C=CC=CC=1>[C:41]([O:16][CH2:15][C:14]([CH3:18])([CH3:17])[C:13](=[O:19])[CH2:12][N:9]1[C:10](=[O:11])[C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[S:40][C:6]=2[N:7]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][C:37](=[O:39])[O:36][N:35]=3)=[CH:24][CH:23]=2)[C:8]1=[O:20])(=[O:43])[CH3:42]

Participants

6

Reactant 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 136052343HCID 136052343, compound

Product 1

HCID 136052270HCID 136052270, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 6-ethyl-3-(4-hydroxy-3,3-dimethyl-2-oxobutyl)-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (0.1 g) in pyridine (0.5 mL) was added acetic anhydride (0.034 mL), and the mixture was stirred at room temperature for 15 hr. To the reaction mixture were added ethyl acetate and water, and the mixture was extracted with ethyl acetate.

Workup

  1. extractionthe mixture was extracted with ethyl acetate

Sources & evidence

ORD record
ord-fe4c318bfcb147b39a70005a051e3a5e
Source dataset
uspto-grants-2013_08
Patent number
US08501750B2

Reaction notes

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