反应详情

2-Amino-5-chlorobenzophenone (2.92 g, 12.60 mmol) was dissolved in 60 mL of pyridine and 4-cyanobenzenesulfonyl chloride (2.66 g, 13.2 mmol) in 10 mL pyridine was then added. The mixture was stirred overnight at room temperature under N2, then poured in a steady stream into 350 mL vigorously stirring chilled 6M HCl which resulted in the precipitation of a yellow solid which was collected by vacuum filtration, washed well with H2O, then dissolved in 50 mL EtOAc and the solvents removed under vacuum to get a reddish powder which was dissolved in 75 mL boiling acetone. 150 mL of H2O was added in a slow stream to the hot, stirring acetone solution. A yellow precipitate formed upon cooling which was collected by vacuum filtration and dried overnight under vacuum to get 5.7 g product as a reddish powder (quant). 1H NMR (DMSO) δ 10.28 (s, 1H) 7.92 (dd, J=1.6, 8.8, 2H) 7.70 (d, 2H) 7.64(t, 1H) 7.58-7.52 (m, 3H) 7.50-7.46 (m, 2H) 7.42 (d, J=2.8 Hz, 1H) 7.03 (d, 8.8 Hz, 1H). MS: m/z =397.0 (M++1).

1. additionpoured in a steady stream into 350 mL
2. stirringvigorously stirring
3. customresulted in the precipitation of a yellow solid which
4. filtrationwas collected by vacuum filtration
5. washwashed well with H2O
6. dissolutiondissolved in 50 mL EtOAc
7. customthe solvents removed under vacuum
8. customto get a reddish powder which
9. dissolutionwas dissolved in 75 mL
10. customA yellow precipitate formed
11. temperatureupon cooling which
12. filtrationwas collected by vacuum filtration
13. customdried overnight under vacuum