反应详情

[8-(2-Methoxy-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-yl]-(1,2,3,4-tetrahydro-isoquinolin-6-yl)-amine was prepared from 6-[8-(2-methoxy-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester and trifluoroacetic acid (1 mL) in a manner analogous to Example 312 to give product (0.255 g). MP=99-103° C. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.47 (s, 1H), 8.79 (d, 1H), 7.95 (s, 1H), 7.80 (d, 1H), 7.62 (d, 1H), 7.38 (m, 3H), 7.05 (t, 1H), 6.85 (d, 1H), 3.85 (s, 3H), 3.75 (s, 2H), 2.92 (m, 2H), 2.63 (br m, 3H): MS=440 (MH)+.