反应详情

[8-(2-Fluoro-3-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-yl]-(4-piperidin-4-yl-phenyl)-amine was prepared from 4-{4-[8-(2-fluoro-3-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester (0.312 g, 0.603 mmol) and trifluoroacetic acid (1 mL) in a manner analogous to Example 312 to give product (0.248 g, 98%). MP=98-101° C. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.61 (s, 1H), 8.83 (d, 1H), 7.60 (m, 3H), 7.25 (m, 3H), 7.10 (m, 3H), 3.90 (s, 3H), 3.05 (m, 2H), 2.55 (br m, 4H), 1.65 (m, 2H), 1.45 (m, 2H). MS=418 (MH)+.