2-Bromo-1-(4-hydroxyphenyl)ethanone → HCID 67135648, compound

HRID 1890168Notes

Reaction equation

HRID 1890168 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([I:19])=[CH:15][N:14]=1>C(#N)C>[BrH:1].[OH:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:12]=[C:13]3[CH:18]=[CH:17][C:16]([I:19])=[CH:15][N:14]3[CH:2]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 49642-Bromo-1-(4-hydroxyphenyl)ethanoneHCID 885792-Pyridinamine, 5-iodo-

Product 1

HCID 67135648HCID 67135648, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

First, 2-bromo-4′-hydroxyacetophenone and 2-amino-5-iodopyridine are dissolved in an inactive solvent such as acetonitrile, and are allowed to react with each other at a reflux temperature for 2 to 6 hours to produce 2-(4′-hydroxyphenyl)-6-iodoimidazo[1,2-a]pyridine hydrobromide salt as white precipitates. The solvent used in this instance may be acetonitrile or another solvent that is usually employed in a similar reaction, for example, methanol and acetone. The reaction temperature may be a temperature allowing refluxing, for example, 110° C. when the solvent is acetonitrile. The amount of the solvent to be used may be an amount sufficient to effect the reaction, however, it should be noted that if the solvent is too much, it will become difficult to obtain precipitates of reaction products. For example, when 2-bromo-4′-hydroxyacetophenone in an amount corresponding to 10 mmol is used for the reaction, the amount of a solvent to be used can be about 40 to 80 mL.

Workup

  1. customto react with each other at a reflux temperature for 2 to 6 hours

Sources & evidence

ORD record
ord-180781c0e366477485e231ce99de7d0e
Source dataset
uspto-grants-2013_08
Patent number
US08506930B2

Reaction notes

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