反应详情

To a reaction vessel containing inert atmosphere, e.g., nitrogen, was added diethyl phosphite, paraformaldehyde, triethylamine and toluene, the mixture was heated for 4-8 hours until TLC showing no diethyl phosphate remaining. After cooling to below 0° C., to the mixture was added a solution of p-toluenesulfonyl chloride toluene and triethylamine, after completion of the reaction, diethyl p-toluenesulfonyloxymethylphosphonate (C) was obtained;

1. additionTo a reaction vessel containing inert atmosphere, e.g., nitrogen
2. temperaturethe mixture was heated for 4-8 hours until TLC
3. temperatureAfter cooling to below 0° C., to the mixture
4. customafter completion of the reaction