(2,4-Dichlorophenyl)boronic acid → HCID 178515770, compound

HRID 1890311Notes

Reaction equation

HRID 1890311 reaction equation
C([O:8][C:9]1[N:14]=[C:13]2[NH:15][CH:16]=[N:17][C:12]2=[CH:11][CH:10]=1)C1C=CC=CC=1.[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1B(O)O>>[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[N:15]1[C:13]2=[N:14][C:9]([OH:8])=[CH:10][CH:11]=[C:12]2[N:17]=[CH:16]1

Participants

3

Reactant 2

HCID 2734659(2,4-Dichlorophenyl)boronic acidHCID 178420377HCID 178420377, compound

Product 1

HCID 178515770HCID 178515770, compound

Procedure

From 5-(benzyloxy)-3H-imidazo[4,5-b]pyridine and 2,4-dichlorophenylboronic acid, prepared in a similar manner as the one described in Example 1.26, the title compound was obtained. LCMS m/z=279.9 [M+H]+; 1H NMR (400 MHz, methanol-d4) δ ppm 6.72 (d, J=8.7 Hz, 1H), 7.57 (dd, J1=8.5 Hz, J2=2.2 Hz, 1H), 7.63 (d, J=8.5 Hz, 1H), 7.79 (d, J=2.2 Hz, 1H), 7.99 (d, J=8.7 Hz, 1H), 8.34 (s, 1H).

Sources & evidence

ORD record
ord-687d384e50754a31aa830cff3773256e
Source dataset
uspto-grants-2013_08
Patent number
US08507473B2

Reaction notes

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