3-Chloro-2-fluorophenylboronic Acid → HCID 178515769, compound

HRID 1890312Notes

Reaction equation

HRID 1890312 reaction equation
C([O:8][C:9]1[N:14]=[C:13]2[NH:15][CH:16]=[N:17][C:12]2=[CH:11][CH:10]=1)C1C=CC=CC=1.[Cl:18][C:19]1[C:20]([F:28])=[C:21](B(O)O)[CH:22]=[CH:23][CH:24]=1>>[Cl:18][C:19]1[C:20]([F:28])=[C:21]([N:15]2[C:13]3=[N:14][C:9]([OH:8])=[CH:10][CH:11]=[C:12]3[N:17]=[CH:16]2)[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 162171583-Chloro-2-fluorophenylboronic AcidHCID 178420377HCID 178420377, compound

Product 1

HCID 178515769HCID 178515769, compound

Procedure

From 5-(benzyloxy)-3H-imidazo[4,5-b]pyridine and 3-chloro-2-fluorophenylboronic acid, prepared in a similar manner as the one described in Example 1.26, the title compound was obtained. LCMS m/z=263.9 [M+H]+; 1H NMR (400 MHz, methanol-d4) δ ppm 6.73 (d, J=8.7 Hz, 1H), 7.39 (td, J1=8.2 Hz, J2=1.5 Hz, 1H), 7.68 (m, 2H), 8.00 (d, J=8.7 Hz, 1H), 8.36 (s, 1H).

Sources & evidence

ORD record
ord-9b317766ce8e4f4cade738b1729f67a5
Source dataset
uspto-grants-2013_08
Patent number
US08507473B2

Reaction notes

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