Cyanogen Bromide → HCID 67312396, compound

Participants

Reaction Steps

A solution of 6-(benzyloxy)-N2-phenylpyridine-2,3-diamine (3.106 g, 10.66 mmol), and cyanogen bromide (1.694 g, 15.99 mmol) in EtOH (50 mL) was stirred overnight at room temperature. The mixture was diluted with EtOAc and saturated NaHCO3. The layers were separated and the aqueous phase was back-extracted with EtOAc. The organics were dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography to give the title compound (446 mg). LCMS m/z=317.1 [M+H]+.

Provenance & Evidence