反应详情

A solution of 6-(benzyloxy)-N2-phenylpyridine-2,3-diamine (3.106 g, 10.66 mmol), and cyanogen bromide (1.694 g, 15.99 mmol) in EtOH (50 mL) was stirred overnight at room temperature. The mixture was diluted with EtOAc and saturated NaHCO3. The layers were separated and the aqueous phase was back-extracted with EtOAc. The organics were dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography to give the title compound (446 mg). LCMS m/z=317.1 [M+H]+.

1. customThe layers were separated
2. extractionthe aqueous phase was back-extracted with EtOAc
3. dry with materialThe organics were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe residue was purified by silica gel chromatography