2,4-Dimethoxybenzoic acid → HCID 44176533, compound

HRID 1890425Notes

Reaction equation

HRID 1890425 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH:11]([NH2:13])[C:10]2=[N:14][C:15]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[CH:16][C:17](=[O:18])[N:9]2[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:25][O:26][C:27]1[CH:35]=[C:34]([O:36][CH3:37])[CH:33]=[CH:32][C:28]=1[C:29](O)=[O:30].ClC1C=CC(C(O)=O)=C(OC)C=1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH:11]([NH:13][C:29](=[O:30])[C:28]2[CH:32]=[CH:33][C:34]([O:36][CH3:37])=[CH:35][C:27]=2[O:26][CH3:25])[C:10]2=[N:14][C:15]([C:19]3[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=3)=[CH:16][C:17](=[O:18])[N:9]2[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 70522,4-Dimethoxybenzoic acidHCID 936824-Chloro-o-anisic acidHCID 66841894HCID 66841894, compound

Product 1

HCID 44176533HCID 44176533, compound

Procedure

By analogy with the method described in example 1 (step 1.8), using 9-amino-4-oxo-2-pyridin-4-yl-5,6,8,9-tetrahydro-4H-1,4a,7-triaza-benzocycloheptene-7-carboxylic acid ethyl ester and 2,4-dimethoxy-benzoic acid in place of (+/−)-9-amino-4-oxo-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-4H-1,4a,7-triaza benzocycloheptene-7-carboxylic acid ethyl ester hydrobromide (1:1) and 4-chloro-2-methoxy-benzoic acid, the compound, 0.103 g (76%), was obtained as a white powder.

Workup

  1. customthe compound, 0.103 g (76%), was obtained as a white powder

Sources & evidence

ORD record
ord-4e7bc9a4669d4734973838c8fcde1f72
Source dataset
uspto-grants-2013_08
Patent number
US08507476B2

Reaction notes

Loading…