HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Methoxy-1,2-dihydroquinoxalin-2-one → 3-(7-methoxy-2-oxo-2H-quinoxalin-1-ylmethyl)-azetidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Methoxy-1,2-dihydroquinoxalin-2-one | HCID 491319 | — |
| Reactant | Tert-butyl 3-((methanesulfonyloxy)methyl)azetidine-1-carboxylate | HCID 21959416 | — |
| Product | 3-(7-methoxy-2-oxo-2H-quinoxalin-1-ylmethyl)-azetidine-1-carboxylic acid tert-butyl ester | HCID 67130867 | 35.7% |
Reaction Steps
Using the procedure of Example 2, step 2.i, but starting from 7-methoxy-2(1H)-quinoxalinone (1.00 g; prepared according to WO 2006/134378) and 3-[[(methylsulfonyl)oxy]methyl]-1-azetidinecarboxylic acid tert-butyl ester (1.65 g; prepared according to WO 02/066470), the second eluting compound was isolated as a yellow oil (700 mg, 35% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507478B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-a36b14d8feac4a84bbd60456c9333f2d |
| Source note | uspto-grants-2013_08 |