HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Methoxy-3,4-dihydroquinolin-2(1H)-one → 3-(7-methoxy-2-oxo-3,4-dihydro-2H-quinolin-1-ylmethyl)-azetidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Methoxy-3,4-dihydroquinolin-2(1H)-one | HCID 12899418 | — |
| Reactant | Tert-butyl 3-((methanesulfonyloxy)methyl)azetidine-1-carboxylate | HCID 21959416 | — |
| Product | 3-(7-methoxy-2-oxo-3,4-dihydro-2H-quinolin-1-ylmethyl)-azetidine-1-carboxylic acid tert-butyl ester | HCID 67130905 | 71% |
Reaction Steps
Using the procedure of Example 2, step 2.i, but starting from 3,4-dihydro-7-methoxy-2(1H)-quinolinone (prepared according to WO 2006/134378; 886 mg) and 3-[[(methylsulfonyl)oxy]methyl]-1-azetidinecarboxylic acid tert-butyl ester (1459 mg; prepared according to WO 02/066470), the title compound was isolated as a colourless oil (1223 mg; 71% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507478B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-eff5ee2b9e65422184cc2fe04e7d37c3 |
| Source note | uspto-grants-2013_08 |