HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate → HCID 67332218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate | HCID 4183641 | — |
| Reactant | 7-Methoxy-1,2-dihydroquinolin-2-one | HCID 29942756 | — |
| Product | HCID 67332218 | HCID 67332218 | 23% |
Reaction Steps
Using the procedure of Example 2, step 2.i, but starting from 7-methoxy-2(1H)-quinolinone (prepared according to WO 2006/134378; 500 mg) and 3-[[(methylsulfonyl)oxy]methyl]-1-pyrrolidinecarboxylic acid tert-butyl ester (797 mg; prepared according to J. Med. Chem. (1999), 42, 677-690), the second eluting compound was isolated as a colourless oil (240 mg; 23% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507478B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-1bd45094ee90481faf3181f2fa2bfb6c |
| Source note | uspto-grants-2013_08 |