Dimethylamine → HCID 10750222, compound

HRID 1890488Notes

Reaction equation

HRID 1890488 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=1.[CH3:12][NH:13][CH3:14]>CO.C(OCC)(=O)C>[CH3:12][N:13]([CH3:14])[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 674DimethylamineHCID 27739122-Chloro-4-(trifluoromethyl)pyrimidine

Product 1

HCID 10750222HCID 10750222, compoundYield 67%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
60 °C

Procedure

2-Chloro-4-trifluoromethylpyrimidine (600 μL, 5.0 mmol) was dissolved with 2.0M dimethylamine in methanol (10 mL), and stirred for 2 hours in a sealed tube at 60° C. The reaction mixture was diluted with ethyl acetate (50 mL), and the whole was washed with water (50 mL) and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 640 mg of the title Reference Compound as a colorless oil (Yield: 67%).

Workup

  1. washthe whole was washed with water (50 mL)
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c6aa95e141f348ad9712e43520445234
Source dataset
uspto-grants-2013_08
Patent number
US08507485B2

Reaction notes

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