Thionyl Chloride → HCID 67305098, compound

HRID 1890511Notes

Reaction equation

HRID 1890511 reaction equation
[S:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH2:10]O.O=S(Cl)[Cl:14]>ClCCl>[Cl:14][CH2:10][C:2]1[S:1][C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 13220437thieno[3,2-b]pyridin-2-ylmethanol

Product 1

HCID 67305098HCID 67305098, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of thieno[3,2-b]pyridin-2-ylmethanol (C-4) (17 mg, 0.1 mmol) in anhydrous dichloromethane (10 mL) was added SOCl2 (120 mg). After the mixture was stirred at room temperature for 2 hours, it was concentrated and used for the next step without further purification. MS (m/z): 184 (M+1)+.

Workup

  1. concentrationit was concentrated
  2. customused for the next step without further purification

Sources & evidence

ORD record
ord-11a18eba2cf64383a2ca13b696238e4a
Source dataset
uspto-grants-2013_08
Patent number
US08507487B2

Reaction notes

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