HCID 88922490, compound → HCID 68285281, compound

HRID 1890616Notes

Reaction equation

HRID 1890616 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH:16]([C:18]4[CH:19]=[CH:20][C:21]([NH:24]C=O)=[N:22][CH:23]=4)[CH3:17])[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1>Cl.CO>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH:16]([C:18]4[CH:19]=[CH:20][C:21]([NH2:24])=[N:22][CH:23]=4)[CH3:17])[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1

Participants

3

Reactant 1

HCID 88922490HCID 88922490, compound

Product 1

HCID 68285281HCID 68285281, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

A solution of compound 330-a (300 mg) in 10 mL of HCl/CH3OH was stirred overnight, then concentrated and basified with Na2CO3 solution. The resulting mixture was purified by chromatography to afford the title compound as a solid, 155 mg.

Workup

  1. concentrationconcentrated
  2. customThe resulting mixture was purified by chromatography

Sources & evidence

ORD record
ord-6876c9fedc914a8c84a2d2940e85d4c2
Source dataset
uspto-grants-2013_08
Patent number
US08507487B2

Reaction notes

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