Water → HCID 23156205, 화합물

HRID 1890622노트

반응식

HRID 1890622 반응식
[CH2:1]([C:3]1[NH:12][C:6]2=[N:7][CH:8]=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2].O.[OH-].[Li+].[N+:16]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Br)=[CH:21][CH:20]=1)([O-:18])=[O:17].O>CN(C=O)C>[CH2:1]([C:3]1[N:12]([CH2:23][C:22]2[CH:25]=[CH:26][C:19]([N+:16]([O-:18])=[O:17])=[CH:20][CH:21]=2)[C:6]2=[N:7][CH:8]=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 660114-Nitrobenzyl bromideHCID 168937Lithium hydroxide, monohydrateHCID 178437450HCID 178437450, 화합물

생성물 1

HCID 23156205HCID 23156205, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-Ethyl-7-methyl-3H-imidazo[4,5-b]pyridine (1.00 g, 6.20 mmol) was dissolved in DMF (15 mL) and lithium hydroxide monohydrate (0.391 g, 9.31 mmol) was added at room temperature followed by stirring for 20 minutes. Then, 4-nitrobenzylbromide (1.34 g, 6.20 mmol) was slowly added to the mixture, and stirred at room temperature. After 30 minutes, water (20 mL) was added and precipitated crystals were collected by filtration, followed by washing with water. The crystals were dried under reduced pressure to obtain Compound P34 (0.819 g, 2.76 mmol, 45%).

후처리

  1. stirringstirred at room temperature
  2. waitAfter 30 minutes
  3. customprecipitated crystals
  4. filtrationwere collected by filtration
  5. washby washing with water
  6. customThe crystals were dried under reduced pressure
  7. customto obtain Compound P34 (0.819 g, 2.76 mmol, 45%)

출처 및 근거

ORD 기록
ord-50846dc2875c41b4bd05839c71ba5cff
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507484B2

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