反应详情

[4-(tert-Butyldimethylsilyloxymethyl)phenyl][3-(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)phenyl]methanol (0.923 g, 1.78 mmol) obtained in Step 3 was dissolved in chloroform (20 mL), and Manganese(IV) oxide (3.11 g, 35.8 mmol) was added to the solution, followed by stirring overnight. The unsoluble material was filtered out through Celite, and the filtrate was combined and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=2:1) to obtain {4-[3-(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)benzoyl]benzyloxy}-tert-butyldimethylsilane (0.898 g, yield 98%).

1. filtrationThe unsoluble material was filtered out through Celite
2. concentrationconcentrated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=2:1)