HCID 69434808, compound → HCID 69435422, compound

Participants

Reaction Steps

[4-(tert-Butyldimethylsilyloxymethyl)phenyl][3-(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)phenyl]methanol (0.923 g, 1.78 mmol) obtained in Step 3 was dissolved in chloroform (20 mL), and Manganese(IV) oxide (3.11 g, 35.8 mmol) was added to the solution, followed by stirring overnight. The unsoluble material was filtered out through Celite, and the filtrate was combined and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=2:1) to obtain {4-[3-(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)benzoyl]benzyloxy}-tert-butyldimethylsilane (0.898 g, yield 98%).

Provenance & Evidence