反应详情

温度

90 °C

Into a solution of N-[1-(aminocarbonyl)cyclopentyl]-2-chlorobenzamide from Step A (0.51 g, 1.912 mmol) in methanol (10 mL) was added NaOH (1.15 mL, 5 N). This solution was heated at 90° C. for 2.5 h. After allowing the reaction mixture to cool, the bulk of the solvent was removed in vacuo to give a residue, which was then neutralized by the addition of 1 N HCl and diluted with DCM. The layers were separated and the aqueous layer was extracted with an additional volume of DCM. The combined organics were dried over sodium sulfate, filtered, and concentrated in vacuo to yield the title compound as a white solid. MS: m/z=249 (M+1).

1. temperatureto cool
2. customthe bulk of the solvent was removed in vacuo
3. customto give a residue, which
4. customThe layers were separated
5. extractionthe aqueous layer was extracted with an additional volume of DCM
6. dry with materialThe combined organics were dried over sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuo