反应详情

温度

100 °C

To the reaction vessel containing 2-benzyl-5-bromo-1,2,3,4-tetrahydro-2,6-naphthyridine (272 mg, 0.9 mmol), 3-(isoquinolin-3-yl)-4-methylaniline (210 mg, 0.9 mmol), Pd2(dba)3 (41 mg, 0.045 mmol), Xantphos (52 mg, 0.09 mmol) and K3PO4 (477 mg, 2.25 mmol) is added anhydrous dioxane (5 mL). The vessel is flushed with nitrogen, sealed and heated to 100° C. for 18 hours. The reaction is then cooled to ambient temperature, filtered through a celite pad to remove any salts. The filtrate is concentrated and purified by silica gel flash chromatography to afford 6-benzyl-N-(3-(isoquinolin-3-yl)-4-methylphenyl)-5,6,7,8-tetrahydro-2,6-naphthyridin-1-amine as an off-white solid. MS m/z 457.2 (M+1).

1. customThe vessel is flushed with nitrogen
2. customsealed
3. temperatureThe reaction is then cooled to ambient temperature
4. filtrationfiltered through a celite pad
5. customto remove any salts
6. concentrationThe filtrate is concentrated
7. custompurified by silica gel flash chromatography