Water → HCID 58486431, compound

HRID 1890766Notes

Reaction equation

HRID 1890766 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[S:8][C:9]([C:16]([O:18]CC)=[O:17])=[C:10]([C:12]([F:15])([F:14])[F:13])[N:11]=2)[CH2:3][CH2:2]1.[OH-].[Na+].O>CO>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[S:8][C:9]([C:16]([OH:18])=[O:17])=[C:10]([C:12]([F:14])([F:13])[F:15])[N:11]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 1490754HCID 1490754, compound

Product 1

HCID 58486431HCID 58486431, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Add ethyl 2-morpholino-4-(trifluoromethyl)thiazole-5-carboxylate (4.58 g, 14.8 mmol) to a mixture of 1 N NaOH (20 mL) in MeOH (20 mL), and heat the reaction to 50° C. for 1 h. Concentrate the reaction under reduced pressure, and add H2O to the residue. Acidify the mixture to pH 4, and filter the solid. Wash the solid with H2O, and dry to obtain the title compound (4.13 g, 99%). ES/MS m/z 283.0 (M+1).

Workup

  1. temperatureheat
  2. customthe reaction to 50° C. for 1 h
  3. concentrationConcentrate
  4. customthe reaction under reduced pressure
  5. filtrationfilter the solid
  6. washWash the solid with H2O
  7. customdry

Sources & evidence

ORD record
ord-a57aa66823614b23a6360df14f6fbee8
Source dataset
uspto-grants-2013_08
Patent number
US08507490B2

Reaction notes

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