Water → HCID 58486431, compound

Participants

Reaction Steps

Add ethyl 2-morpholino-4-(trifluoromethyl)thiazole-5-carboxylate (4.58 g, 14.8 mmol) to a mixture of 1 N NaOH (20 mL) in MeOH (20 mL), and heat the reaction to 50° C. for 1 h. Concentrate the reaction under reduced pressure, and add H2O to the residue. Acidify the mixture to pH 4, and filter the solid. Wash the solid with H2O, and dry to obtain the title compound (4.13 g, 99%). ES/MS m/z 283.0 (M+1).

Provenance & Evidence