Hydrochloric Acid → HCID 68407646, compound

HRID 1890780Notes

Reaction equation

HRID 1890780 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]#[N:13])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH2:14]([OH:16])[CH3:15].Cl>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:12](=[NH:13])[O:16][CH2:14][CH3:15])[CH2:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 986211-(4-Chlorophenyl)cyclobutanecarbonitrile

Product 1

HCID 68407646HCID 68407646, compound

Procedure

Through a cooled solution of 1-(4-chlorophenyl)cyclobutanecarbonitrile (5.0 g, 26.1 mmol, Aldrich) and ethanol (2.3 mL, 39.1 mmol) was bubbled HCl gas at 0° C. for 30 minutes. After standing at 4° C. for 24 hours, the reaction mixture was concentrated and triturated with diethyl ether. The precipitate was collected and dried to obtain the titled compound. MS (ESI+) m/z 238 (M+H)1.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customtriturated with diethyl ether
  3. customThe precipitate was collected
  4. customdried

Sources & evidence

ORD record
ord-aa2bd2377c7b4ea8a3965de239febc17
Source dataset
uspto-grants-2013_08
Patent number
US08507493B2

Reaction notes

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