Hydrochloric Acid → HCID 86646768, compound

HRID 1890784Notes

Reaction equation

HRID 1890784 reaction equation
[Cl:1][C:2]1[C:7]([CH2:8][C:9]#[N:10])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([OH:13])[CH3:12].Cl>ClCCl>[Cl:1][C:2]1[C:7]([CH2:8][C:9](=[NH:10])[O:13][CH2:11][CH3:12])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 147395432-(2-Chloropyridin-3-yl)acetonitrile

Product 1

HCID 86646768HCID 86646768, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Through a cooled solution of 2-(2-chloropyridin-3-yl)acetonitrile (Synthesis (6), 528-30, 1992) (1.7 g, 11.1 mmol), ethanol (1.0 mL, 16.7 mmol), and dichloromethane (25 mL) was bubbled HCl gas at 0° C. for 30 minutes. After standing at 4° C. for 24 hours, the reaction mixture was concentrated, and the residue was triturated with diethyl ether. The precipitate was collected and dried to obtain the titled compound. MS (ESI+) m/z 199 (M+H)+.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customthe residue was triturated with diethyl ether
  3. customThe precipitate was collected
  4. customdried

Sources & evidence

ORD record
ord-036f90db25f248a7b655809e66544857
Source dataset
uspto-grants-2013_08
Patent number
US08507493B2

Reaction notes

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