Hydrochloric Acid → HCID 68405906, compound

HRID 1890795Notes

Reaction equation

HRID 1890795 reaction equation
[F:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[O:4][C:5]([CH3:9])([CH3:8])[C:6]#[N:7].[CH2:15]([OH:17])[CH3:16].[ClH:18]>C(Cl)Cl>[ClH:18].[F:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[O:4][C:5]([CH3:9])([CH3:8])[C:6](=[NH:7])[O:17][CH2:15][CH3:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 57467467HCID 57467467, compound

Product 1

HCID 68405906HCID 68405906, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Through a cooled solution of Example 51B (6.5 g, 33 mmol) and ethanol (9.6 mL, 165 mmol) in methylene chloride (10 ml) was bubbled HCl gas at 0° C. for 30 minutes. The reaction was kept in a refrigerator at 4° C. for 60 hours. The reaction mixture was then concentrated and triturated with diethyl ether to obtain a precipitate of the titled compound. MS (ESI+) m/z 244 (M+H)+.

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. customtriturated with diethyl ether

Sources & evidence

ORD record
ord-e44950cb3dab4425977f7bf4734db44e
Source dataset
uspto-grants-2013_08
Patent number
US08507493B2

Reaction notes

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