Dimethylformamide dimethyl acetal → HCID 178484325, compound

HRID 1890904Notes

Reaction equation

HRID 1890904 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([NH2:10])=[O:9])=[N:6][CH:7]=1.CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](/[N:10]=[CH:13]/[N:14]([CH3:16])[CH3:15])=[O:9])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 7351515-Bromopyridine-2-carboxamide

Product 1

HCID 178484325HCID 178484325, compoundYield 95%

Procedure

A solution of 5-bromopicolinamide (0.500 g, 2.49 mmol) and dimethylformamide dimethylacetal (20 mL), were heated to 85° C. for 3 h. The reaction was concentrated and the product was used directly in the next step (0.604 g, 95% yield). MS (ESI) m/z 257.1 [M+1]+.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-03efd30a6e664845a3376e6b68a92ee9
Source dataset
uspto-grants-2013_08
Patent number
US08507492B2

Reaction notes

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