Hydrazine hydrate (1:1) → 3-Hydrazinyl-6-methylpyridazine

HRID 1890955Notes

Reaction equation

HRID 1890955 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.O.[NH2:10][NH2:11]>C(O)C>[CH3:8][C:5]1[N:4]=[N:3][C:2]([NH:10][NH2:11])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2272543-Chloro-6-methylpyridazine

Product 1

HCID 123798043-Hydrazinyl-6-methylpyridazineYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 3-chloro-6-methyl-pyridazine (3 g, 23.3 mmol) in ethanol (45 mL) was added hydrazine hydrate (45 mL) and the resultant mixture was heated to reflux for 3 hrs. Most of the solvent was removed under reduced pressure and the white solid was collected by filtration and washed with ethanol. Upon drying 2.3 g of (6-methyl-pyridazin-3-yl)-hydrazine was obtained as a white crystalline solid (80% yield).

Workup

  1. temperatureto reflux for 3 hrs
  2. customMost of the solvent was removed under reduced pressure
  3. filtrationthe white solid was collected by filtration
  4. washwashed with ethanol
  5. dry with materialUpon drying 2.3 g of (6-methyl-pyridazin-3-yl)-hydrazine

Sources & evidence

ORD record
ord-f1c987e522a24dffb51a96aa64b730a9
Source dataset
uspto-grants-2013_08
Patent number
US08507489B2

Reaction notes

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