HCID 24902159, compound → HCID 25132978, compound

HRID 1890980Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][S:9]([NH-:12])(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.Cl[C:14]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH2:26][CH3:27])[N:17]=[CH:16][N:15]=1>CN(C=O)C>[CH2:26]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:18]1[N:17]=[CH:16][N:15]=[C:14]([NH:1][C:2]2[CH:3]=[C:4]([CH2:8][S:9]([NH2:12])(=[O:10])=[O:11])[CH:5]=[CH:6][CH:7]=2)[CH:19]=1)[CH3:27]

Participants

Conditions

Temperature: 80 °C

Procedure

A mixture of (3-aminophenyl)methanesulfonyl amide (0.112 g, 0.60 mmol) and 4-chloro-6-(2-ethylphenyl)-pyrimidine (0.131 g, 0.60 mmol) in DMFA (3 mL) was stirred at 80° C. till the reaction completion (TLC control), then concentrated in vacuo, and the residue was recrystallized from isopropanol to give {3-[6-(2-ethyl-phenyl)-pyrimidin-4-ylamino]-phenyl}-methanesulfonamide (Compound 26)

Workup

concentrationconcentrated in vacuo
customthe residue was recrystallized from isopropanol

Sources & evidence

ORD record: ord-21ce72215db3430c857d49097a5cc5b9
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08507498B2

Reaction notes

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