HCID 58550503, compound → HCID 16775514, compound

HRID 1890997Notes

Reaction equation

HRID 1890997 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[NH:11][S:12]([CH2:15][CH2:16][CH3:17])(=[O:14])=[O:13]>[Ni].CO>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([NH:11][S:12]([CH2:15][CH2:16][CH3:17])(=[O:14])=[O:13])[CH:4]=1

Participants

4

Reactant 1

HCID 58550503HCID 58550503, compound

Product 1

HCID 16775514HCID 16775514, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

Propane-1-sulfonic acid (2-methyl-5-nitro-phenyl)-amide (10 g, 39 mmol) was hydrogenated over Raney nickel (1.0 g) in methanol at 50° C. and 70 psi for 4 h. Then, the catalyst was filtered out, washed with warm methanol, and the combined filtrates were evaporated to give 8.0 g (90%) of propane-1-sulfonic acid (5-amino-2-methyl-phenyl)-amide as colorless solid.

Workup

  1. filtrationThen, the catalyst was filtered out
  2. washwashed with warm methanol
  3. customthe combined filtrates were evaporated

Sources & evidence

ORD record
ord-8f9a6ebe4dad459aa5af6f7a5040bb49
Source dataset
uspto-grants-2013_08
Patent number
US08507498B2

Reaction notes

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