反应详情

127 mg (0.43 mmol) of (R)-3-[(5-bromo-2-chloropyrimidin-4-yl)amino]-2-methyl-butan-2-ol in 1 ml of acetonitrile is added to 74 mg (0.43 mmol) of (RS)—S-(3-aminophenyl)-S-methyl sulfoximide in 0.5 ml of acetonitrile. It is mixed with 0.1 ml of a 4N solution of HCl in dioxane, and the batch is refluxed overnight. The solvent is drawn off, and the remaining residue is purified by chromatography (DCM/EtOH 9:1). 37 mg (0.09 mmol, corresponding to 20% of theory) of the product is obtained.

1. temperaturethe batch is refluxed overnight
2. customthe remaining residue is purified by chromatography (DCM/EtOH 9:1)
3. custom37 mg (0.09 mmol, corresponding to 20% of theory) of the product is obtained