反应详情

温度

106 °C

255 mg of (RS)—S-{4-[(5-bromo-4-hydroxypyrimidin-2-yl)amino]phenyl}-S-methyl sulfoximide is suspended in 1.5 ml of phosphorus oxychloride and stirred for 3 hours at 106° C. and for 16 hours at room temperature. The mixture is poured into ice water, made alkaline with 25% ammonia solution while being cooled intensely (temperature <5° C.) and stirred for 1 hour in an ice bath. The precipitate is suctioned off, washed with water and dried at 60° C. 220 mg (81.8% of theory) of the product with a melting point of 170-173° C. is obtained.

1. temperaturewhile being cooled intensely (temperature <5° C.)
2. stirringstirred for 1 hour in an ice bath
3. washwashed with water
4. customdried at 60° C
5. custom220 mg (81.8% of theory) of the product with a melting point of 170-173° C. is obtained