反应详情

To a solution of PdCl2 (dppf). DCM (10 mg, 0.012 mmol) in anhydrous toluene (4 ml) in an argon filled sealed microwave tube was added the 1-(3-Bromo-phenyl)-4-methyl-piperazine (100 mg, 0.39 mmol), Et3N (0.11 ml, 2 equiv.), and 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (0.09 ml, 1.5 equiv). The microwave tube was evacuated and backfilled with Argon before being irradiated in a CEM Microwave reactor at 100° C. for 1 hr using an initial power of 200 W. The reaction mixture was partitioned between more toluene (6 ml) and water (10 ml), the organic layer separated, washed with water (1×10 ml), dried over MgSO4 and then evaporated in vacuo to leave a purple/brown residue which was used for suzuki coupling without further purification.

1. customsealed microwave tube
2. customThe microwave tube was evacuated
3. custombefore being irradiated in a CEM Microwave reactor at 100° C. for 1 hr
4. customThe reaction mixture was partitioned between more toluene (6 ml) and water (10 ml)
5. customthe organic layer separated
6. washwashed with water (1×10 ml)
7. dry with materialdried over MgSO4
8. customevaporated in vacuo
9. customto leave a purple/brown residue which
10. customwas used for suzuki coupling without further purification