HCID 86644565, compound → HCID 68486762, compound

HRID 1891209Notes

Reaction equation

HRID 1891209 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([C:15]2[N:20]=[C:19]([C:21]3[CH:47]=[CH:46][CH:45]=[C:44]([F:48])[C:22]=3[O:23][CH2:24][C:25]3[CH:30]=[CH:29][C:28]([CH:31]4[CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33][CH2:32]4)=[CH:27][CH:26]=3)[CH:18]=[CH:17][CH:16]=2)[C:10]=1[C:11]([F:14])([F:13])[F:12])=[O:5])[CH3:2]>C(O)(=O)C.O>[F:48][C:44]1[C:22]([O:23][CH2:24][C:25]2[CH:26]=[CH:27][C:28]([CH:31]3[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]3)=[CH:29][CH:30]=2)=[C:21]([C:19]2[N:20]=[C:15]([N:9]3[C:10]([C:11]([F:13])([F:14])[F:12])=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]=[N:8]3)[CH:16]=[CH:17][CH:18]=2)[CH:47]=[CH:46][CH:45]=1

Participants

4

Reactant 1

HCID 86644565HCID 86644565, compound

Product 1

HCID 68486762HCID 68486762, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of the title compound from Example 5 Step B (800 mg, 1.20 mmol) in acetic acid (4 mL) and water (1 mL) was stirred at 90° C. for 14 h. The reaction mixture was allowed to cool to ambient temperature and evaporated in vacuo. The product was used in the subsequent step without further purification: LCMS m/z 568.8 [M+H]+.

Workup

  1. customevaporated in vacuo
  2. customThe product was used in the subsequent step without further purification

Sources & evidence

ORD record
ord-ccd3ed7a8cc7459dacfec73a0dfb60d7
Source dataset
uspto-grants-2013_08
Patent number
US08507512B2

Reaction notes

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