2-Bromopropiophenone → HCID 69812854, compound

HRID 1891235Notes

Reaction equation

HRID 1891235 reaction equation
Br[CH:2]([CH3:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][N:14]=1>CC(C)=O>[Br:19][C:16]1[CH:17]=[CH:18][C:13]2[N:14]([C:2]([CH3:11])=[C:3]([C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:12]=2)[CH:15]=1

Participants

4

Reactant 2

HCID 164522-BromopropiophenoneHCID 706222-Amino-5-bromopyridine

Product 1

HCID 69812854HCID 69812854, compoundYield 24.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In a 100 ml round-bottomed flask, 865 mg of 2-amino-5-bromopyridine are dissolved in 25 ml of acetone, then 1.06 g of 2-bromo-1-phenyl-1-propanone are added and the mixture is heated at the reflux of the solvent for 57 hours. The reaction mixture is allowed to cool and then the precipitate is recovered by filtration, washed with diethyl ether and dried under reduced pressure. 350 mg of compound are obtained.

Workup

  1. temperaturethe mixture is heated at the
  2. temperaturereflux of the solvent for 57 hours
  3. temperatureto cool
  4. filtrationthe precipitate is recovered by filtration
  5. washwashed with diethyl ether
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-4ce78ad6c3af448cb66c729d2c04959c
Source dataset
uspto-grants-2013_08
Patent number
US08507520B2

Reaction notes

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