Sodium borohydride → (3-Bromo-2,6-difluorophenyl)methanol

HRID 1891242Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1891242
[Br:1][C:2]1[C:3]([F:11])=[C:4]([C:7]([F:10])=[CH:8][CH:9]=1)[CH:5]=[O:6].[BH4-].[Na+]>CO>[Br:1][C:2]1[C:3]([F:11])=[C:4]([CH2:5][OH:6])[C:7]([F:10])=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 221397013-Bromo-2,6-difluorobenzaldehyde

Produkt 1

HCID 22219889(3-Bromo-2,6-difluorophenyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

20 g of 3-bromo-2,6-difluorobenzaldehyde are dissolved in 450 ml of methanol and cooled in an ice bath; 3.42 g of sodium borohydride are then added thereto, portionwise. The mixture is stirred at ambient temperature for 1 hour and the solvent is then evaporated off under reduced pressure. The residue is taken up between water and dichloromethane, and the organic phase organic is separated, dried, and concentrated under reduced pressure. The residue is crystallized from n-pentane. 14.6 g of compound, used as it is in the subsequent stage, are obtained.

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. customthe solvent is then evaporated off under reduced pressure
  3. customthe organic phase organic is separated
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customThe residue is crystallized from n-pentane
  7. customare obtained

Quellen und Nachweise

ORD-Eintrag
ord-6431bfaf31974815b58b2ad42eb8770a
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08507520B2

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