反应详情

20 g of 3-bromo-2,6-difluorobenzaldehyde are dissolved in 450 ml of methanol and cooled in an ice bath; 3.42 g of sodium borohydride are then added thereto, portionwise. The mixture is stirred at ambient temperature for 1 hour and the solvent is then evaporated off under reduced pressure. The residue is taken up between water and dichloromethane, and the organic phase organic is separated, dried, and concentrated under reduced pressure. The residue is crystallized from n-pentane. 14.6 g of compound, used as it is in the subsequent stage, are obtained.

1. temperaturecooled in an ice bath
2. customthe solvent is then evaporated off under reduced pressure
3. customthe organic phase organic is separated
4. customdried
5. concentrationconcentrated under reduced pressure
6. customThe residue is crystallized from n-pentane
7. customare obtained