Boron tribromide → HCID 25152881, compound

HRID 1891422Notes

Reaction equation

HRID 1891422 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[O:24]C)[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:14][CH2:13][CH2:12][C:11]1([CH3:16])[CH3:15])=[O:9].B(Br)(Br)Br>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C:17]2[C:18]([OH:24])=[CH:19][CH:20]=[C:21]([F:23])[CH:22]=2)[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:14][CH2:13][CH2:12][C:11]1([CH3:16])[CH3:15])=[O:9]

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 25152884HCID 25152884, compound

Product 1

HCID 25152881HCID 25152881, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent3×

Procedure

The product from step c) (0.6 g) in DCM (10 mL) was treated with 1.0 M boron tribromide in DCM (5 mL) and the reaction was stirred at rt overnight. The reaction was diluted with DCM and washed with ice water, dried (MgSO4) and concentrated under reduced pressure to give the sub titled product as a solid (0.5 g).

Workup

  1. washwashed with ice water
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b09a0aeb5ff54481951258ef1757d4a3
Source dataset
uspto-grants-2013_08
Patent number
US08507544B2

Reaction notes

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