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HRID1891455

反应详情

EQUATION

反应方程式

HRID 1891455 的结构方程式

REACTANTS

反应物

2
结构：CC(C)[O-].[Na+]
HCID10920443

2-Propanol, sodium salt (1:1)

C3H7NaO

结构：CC(C)(C)[Si](C)(C)O[C@H]1CCc2c(-c3cnc(-c4ccc(F)c(C#N)c4)s3)cccc21
HCID58367337

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)Oc1ccc(-c2ncc(-c3cccc4c3CC[C@@H]4O[Si](C)(C)C(C)(C)C)s2)cc1C#N
HCID58367092

未命名化合物

收率 123.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

Prepared using General Procedure 2. To a solution of (S)-5-(5-(1-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-fluorobenzonitrile (116 mg, 0.25 mmol) in IPA (2 mL) was added sodium isopropoxide (21.1 mg, 0.25 mmol). The reaction mixture was heated at 60° C. for 2 h. Upon cooling, the solvent was evaporated and the product was purified by a silica gel column chromatography (EA/hexanes) to afford 151 mg (88%) of (S)-5-(5-(1-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxy-benzonitrile LCMS-ESI (m/z) calculated for C28H34N2O2SSi: 490.7, found 491.1 [M+H]+, tR=6.81 min (Method 1).

WORKUP

后处理

  1. customPrepared
  2. temperatureUpon cooling
  3. customthe solvent was evaporated
  4. customthe product was purified by a silica gel column chromatography (EA/hexanes)