Sodium Hydroxide → HCID 25052752, compound

HRID 1891984Notes

Reaction equation

HRID 1891984 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][CH2:8][C:9]1[CH:31]=[CH:30][C:12]([CH2:13][C:14]2[CH:18]=[C:17]([C:19]3[C:20]([NH:25][P:26](=[O:29])([OH:28])[OH:27])=[N:21][CH:22]=[CH:23][CH:24]=3)[O:16][N:15]=2)=[CH:11][CH:10]=1.[OH-].[Na+:33]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][CH2:8][C:9]1[CH:31]=[CH:30][C:12]([CH2:13][C:14]2[CH:18]=[C:17]([C:19]3[C:20]([NH:25][P:26]([O-:28])([O-:29])=[O:27])=[N:21][CH:22]=[CH:23][CH:24]=3)[O:16][N:15]=2)=[CH:11][CH:10]=1.[Na+:33].[Na+:33]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 25052753HCID 25052753, compound

Product 1

HCID 25052752HCID 25052752, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Alternative method (1): To a mixture of (3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-yl)phosphoramidic acid (7.1 mg, 0.016 mmol) described in Example 2 and methanol (2 mL) was added 1 N aqueous sodium hydroxide solution (0.032 mL) at room temperature, and the solvent was evaporated under a reduced pressure. The resulting residue was washed with dimethyl sulfoxide-ethyl acetate (1:1) to obtain the title compound (7.0 mg, 90%).

Workup

  1. customthe solvent was evaporated under a reduced pressure
  2. washThe resulting residue was washed with dimethyl sulfoxide-ethyl acetate (1:1)

Sources & evidence

ORD record
ord-9cbd4d38feec4426855901934207fa28
Source dataset
uspto-grants-2013_08
Patent number
US08507530B2

Reaction notes

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