Sodium Hydroxide → HCID 25052752, compound

Participants

Reaction Steps

Alternative method (1): To a mixture of (3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-yl)phosphoramidic acid (7.1 mg, 0.016 mmol) described in Example 2 and methanol (2 mL) was added 1 N aqueous sodium hydroxide solution (0.032 mL) at room temperature, and the solvent was evaporated under a reduced pressure. The resulting residue was washed with dimethyl sulfoxide-ethyl acetate (1:1) to obtain the title compound (7.0 mg, 90%).

Provenance & Evidence