反应详情

温度

65 °C

To a solution of 2-(3-Ethynyl-quinolin-6-yloxy)-N-(1-formyl-cyclobutyl)-2-methylsulfanyl-acetamide (125 mg) in ethanol (10 ml) was added sodium acetate (50 mg) and O-methyl hydroxylamine hydrochloride (44 mg), at room temperature. The mixture was heated to 65° C. during 1 hour. After cooling to room temperature the mixture was poured into water and extracted with ethyl acetate (2×10 ml). The organic phase was washed with sat. aq NaCl solution, dried over anhydrous sodium sulphate, filtered and evaporated under vacuum. Purification by flash chromatography (ethyl acetate/cyclohexane, 1/1) gave 2-(3-ethynyl-quinolin-6-yloxy)-N-[1-(methoxyimino-methyl)-cyclobutyl]-2-methylsulfanyl-acetamide (110 mg) as a yellow oil.

1. customat room temperature
2. temperatureAfter cooling to room temperature the mixture
3. extractionextracted with ethyl acetate (2×10 ml)
4. washThe organic phase was washed with sat. aq NaCl solution
5. dry with materialdried over anhydrous sodium sulphate
6. filtrationfiltered
7. customevaporated under vacuum
8. customPurification by flash chromatography (ethyl acetate/cyclohexane, 1/1)