3-Bromoaniline → HCID 68729453, compound

HRID 1892141Notes

Reaction equation

HRID 1892141 reaction equation
[S:1]([N:5]=[C:6]([O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)OC1C=CC=CC=1)(=[O:4])(=[O:3])[NH2:2].[Br:21][C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][CH:28]=1)[NH2:25]>C(#N)C>[Br:21][C:22]1[CH:23]=[C:24]([NH:25][C:6](=[N:5][S:1](=[O:3])(=[O:4])[NH2:2])[O:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 115623-BromoanilineHCID 15599173Diphenyl sulfamoylcarbonimidate

Product 1

HCID 68729453HCID 68729453, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
70 °C

Procedure

Diphenyl sulfamoylcarbonimidate, from step A, (0.05 g, 0.17 mmol) and 3-bromoaniline (18 μl, 0.17 mmol) were dissolved in acetonitrile (0.5 ml) and heated to 70° C. for 12 hours. The reaction was concentrated under vacuum to afford phenyl N-3-bromophenyl-N′-sulfamoylcarbamimidate, which was carried on crude to the next reaction.

Workup

  1. concentrationThe reaction was concentrated under vacuum

Sources & evidence

ORD record
ord-432ff1f5c71147a5b241435db4187179
Source dataset
uspto-grants-2013_08
Patent number
US08507672B2

Reaction notes

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