反应详情

2-(3-nitrophenyl)acetyl chloride (0.20 ml, 1.0 mmol.) was added to a vigorously stirred mixture of tert-butyl piperazine-1-carboxylate (0.19 g, 1.0 mmol.) in CH2Cl2 (2 ml) and sat. aq. NaHCO3 (1 ml). The reaction was stirred for 1 hour; then the organic layer was separated, filtered through a plug of MgSO4, and concentrated under vacuum. The residue was treated with TFA in CH2Cl2 to remove the Boc group to give 2-(3-nitrophenyl)-1-(piperazin-1-yl)ethanone, which was carried on crude.

1. customthen the organic layer was separated
2. filtrationfiltered through a plug of MgSO4
3. concentrationconcentrated under vacuum
4. additionThe residue was treated with TFA in CH2Cl2
5. customto remove the Boc group