反应详情

温度

0 °C

The compound (0.12 g) obtained from step d was taken in acetonitrile (6 mL) and water (1 mL), to this solution sodiumdihydrogen phosphate (0.05 g) was added. Reaction mixture was cooled to 0° C. and hydrogen peroxide (0.5 mL) and sodium chlorite (0.15 g) were added. After stirring the reaction mixture for additional 1 hour, solvents were evaporated on rotaevaporator, the residue was taken into water and extracted with ethyl acetate. Organic layer was washed with water and brine solution and dried over anhydrous sodium sulphate. Solvent was evaporated under the reduced pressure, to get the title compound (0.12 g)

1. customReaction mixture
2. customsolvents were evaporated on rotaevaporator
3. extractionextracted with ethyl acetate
4. washOrganic layer was washed with water and brine solution
5. dry with materialdried over anhydrous sodium sulphate
6. customSolvent was evaporated under the reduced pressure