反应详情

To a solution of 2-(quinolin-6-ylmethyl)isoindoline-1,3-dione (20 g, 69.4 mmol) in MeOH (100 mL) was added hydrazine monohydrate (3.47 g, 69.4 mmol). The solution was heated at reflux for 3 h, then cooled to it and filtered through celite. The filtrate was concentrated in vacuo. EtOAc then was added to the residue and the resulting solution was filtered and concentrated in vacuo to afford 5 g (41%) of the title compound. LCMS (method B): [MH]+=159, tR=0.93 min.

1. temperatureThe solution was heated
2. temperatureat reflux for 3 h
3. temperaturecooled to it
4. filtrationfiltered through celite
5. concentrationThe filtrate was concentrated in vacuo
6. additionEtOAc then was added to the residue
7. filtrationthe resulting solution was filtered
8. concentrationconcentrated in vacuo