Hydrazine hydrate (1:1) → O-((4-Methoxyphenyl)methyl)hydroxylamine

Temperatur

65 °C

To a solution of 2-(4-methoxybenzyloxy)isoindoline-1,3-dione (200 mg, 0.706 mmol) in MeOH (5 mL) was added hydrazine monohydrate (35.3 mg, 0.706 mmol). The reaction mixture was stirred at 65° C. for 1 h. The solvent was removed in vacuo, and the resulting residue was diluted with EtOAc (5 mL). After stirring for 20 min, the mixture was filtered. The filtrate was concentrated in vacuo to afford the title compound. 1H-NMR (400 MHz, CDCl3) δ ppm 7.30 (m, 2H), 6.90 (m, 2H), 4.63 (m, 2H), 3.81 (s, 3H).

1. customThe solvent was removed in vacuo
2. additionthe resulting residue was diluted with EtOAc (5 mL)
3. stirringAfter stirring for 20 min
4. filtrationthe mixture was filtered
5. concentrationThe filtrate was concentrated in vacuo

ORD-Eintrag

ord-4b65b9099afe4afe96aeb94059a22226

Quelldatensatz

uspto-grants-2013_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08507676B2