N-Hydroxyphthalimide → HCID 21751545, compound

HRID 1892293Notes

Reaction equation

HRID 1892293 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1.O[N:17]1[C:25](=[O:26])[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]1=[O:27]>>[O:27]=[C:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:25](=[O:26])[N:17]1[O:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 10665N-HydroxyphthalimideHCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 21751545HCID 21751545, compoundYield 80%

Procedure

The title compound was prepared from t-butyl 4-(hydroxymethyl)piperidine-1-carboxylate and 2-hydroxyisoindoline-1,3-dione in 80% yield using the same procedure as described in the synthesis of intermediate B. LCMS (method B): [MNa]+=383, tR=2.64 min.

Sources & evidence

ORD record
ord-8e422fd60c534c30a75745e86e6afad9
Source dataset
uspto-grants-2013_08
Patent number
US08507676B2

Reaction notes

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