Hydrazine hydrate (1:1) → 3-Chloro-6-hydrazinopyridazine

Participants

Reaction Steps

A solution of 3,6-dichloropyridazine (3 g, 20.14 mmol) and hydrazine monohydrate (1 g, 20.14 mmol) in 20 mL THF in a sealed tube was heated at 80° C. for 5 h. Solvent was evaporated and the crude was used in the next step without purification (3.56 g, 100%). LCMS (method B): [MH]+=145.1, tR=0.574 min.

Provenance & Evidence