Hydrazine hydrate (1:1) → 3-Chloro-6-hydrazinopyridazine

HRID 1892301Notes

Reaction equation

HRID 1892301 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.O.[NH2:10][NH2:11]>C1COCC1>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:10][NH2:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 673313,6-Dichloropyridazine

Product 1

HCID 1007873-Chloro-6-hydrazinopyridazine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3,6-dichloropyridazine (3 g, 20.14 mmol) and hydrazine monohydrate (1 g, 20.14 mmol) in 20 mL THF in a sealed tube was heated at 80° C. for 5 h. Solvent was evaporated and the crude was used in the next step without purification (3.56 g, 100%). LCMS (method B): [MH]+=145.1, tR=0.574 min.

Workup

  1. customSolvent was evaporated
  2. customthe crude was used in the next step without purification (3.56 g, 100%)

Sources & evidence

ORD record
ord-6e3565e82cd240a0a447968386b86b3b
Source dataset
uspto-grants-2013_08
Patent number
US08507676B2

Reaction notes

Loading…